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Tissue engineering in orthopaedic sports medicine: current concepts
  1. João Bebiano Costa1,2,
  2. Helder Pereira1,2,3,4,
  3. João Espregueira-Mendes1,2,3,
  4. Gilson Khang5,
  5. Joaquim Miguel Oliveira1,2,
  6. Rui Luis Reis1,2
  1. 1 3B's Research Group–Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, Guimarães, Portugal
  2. 2 ICVS/3B’s–PT Government Associate Laboratory, Braga/Guimarães, Portugal
  3. 3 Clínica do Dragão - Espregueira-Mendes Sports Centre - FIFA Medical Centre of Excellence, F.C. Porto Stadium, Minho University and Porto University Research Centre, Porto, Portugal
  4. 4 Orthopaedic Department, Centro Hospitalar Póvoa de Varzim, Vila do Conde, Portugal
  5. 5 Department of BIN Fusion Technology and Department of PolymerNano Science and Technology, Chonbuk National University, Jeonju, South Korea
  1. Correspondence to Rui Luis Reis, 3B's Research Group–Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco, Guimarães, Portugal; rgreis{at}dep.uminho.pt

Abstract

Tissue engineering (TE) has been revolutionising the concepts and therapeutic approaches for the treatment of different sports injuries. To overcome the drawbacks of the current treatments, TE-based strategies provided new possibilities, either in the treatment of defects, which were previously considered unrecoverable, but also in what concerns to the decrease of recovery time. Supported in three mainstream concepts, TE uses the combination of scaffolds, cells and biological factors to pursue a better functional regenerative process. Aware of the limitations of today's treatments, the scientific and medical communities have made great effort to apply, in the safest and most efficient manner, the panoply of new TE tools. However, it is important to understand that there is still a long way to go until these new approaches turn out to be the 'gold standard' treatment in the clinics. This review aims to overview the current concepts of TE applications in orthopaedic sports medicine under preclinical and clinical research applied to growth factors, scaffolds and stem cells.

  • Tissue Engineering
  • Orthopedic
  • Growth Factors
  • Scaffolds
  • Sports medicine
  • Stem Cells.

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Footnotes

  • Competing interests None declared.

  • Provenance and peer review Commissioned; externally peer reviewed.

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