Table 1

Main effects and interaction terms tested in the Cox hazard proportions model (1) for conversion to TKR and partial least squares regression models (2, 3) for ΔKOOS-pain (pain relief)

Main effectsInteractions
(1, 2, 3) Bilateral(2, 3) Age*Bilateral
(1, 2, 3) Gender21–25 (2, 3) Age*Gender
(1, 2, 3) Age at surgery (years)10 21 26–28 (2, 3) Age*Ligament reconstruction
(2, 3) BMI at surgery (kg/m2)10 21 22 27–31 (2, 3) Age*Cartilage
(2, 3) KOOS-Pre(2, 3) BMI*Gender
(2, 3) MFC ICRS Grade(2, 3) KOOS Pre*Bilateral
(1, 2, 3) Ever smoked26 (2, 3) KOOS Pre*Gender
(1, 2, 3) Ligament reconstruction(2, 3) KOOS Pre*Cartilage treatment
(1, 2, 3) Cartilage treatment2 (2, 3) KOOS FU*Bilateral
(1, 2, 3) Meniscectomy22 26 (2, 3) KOOS FU*Gender
(2, 3) KOOS follow-up (years)(2, 3) KOOS FU*Cartilage treatment
(3) Preop alignment (°)(3) Preop alignment *gender